Isn’t it important for T-cell maturation? How will the immune system be afectes due to this shrinking?
Yes, T cells mature/develop in the thymus and yes, the thymus shrinks with age through a process called Involution. Occurring in many vertebrates, thymic involution is an ancient and evolutionarily conserved process (1). Let’s examine the thymus in step-wise fashion. How does it shrink? Why is it important? Could mouse models be inconsequential for understanding human thymus function? Finally, why does it shrink with age?
Before proceeding, let’s define a few immunological terms pertinent for this discussion.
Peripheral: Immunologists define the thymus as the site of T cell development/maturation. Everywhere else we find T cells, we call the periphery, and naturally, such T cells we call peripheral, as opposed to thymic, T cells.
Germline: The key identifier of T cells is their T cell receptor (TCR). Immature T cells start out with a TCR we call germline TCR. During T cell development/maturation, this TCR undergoes re-arrangement through genetic recombination to become entirely different from the one the immature T cell started out with.
Senescence: Permanent cell cycle arrest. Hayflick originally identified it in human fibroblasts (2). Senescent cells either no longer divide/can divide. Same concept applied to immune cells is called Immunosenescence (3).
Repertoire: Typically refers to the spectrum of unique TCRs (and BCRs; B cell receptor) in an individual. Naive repertoire refers to the spectrum of new (naive) T and B cells and their receptors.
How does the thymus shrink with age?
Current consensus says thymus shrinks in an age-dependent program. Though the process starts during puberty or even earlier, in middle age adipocytes (fat cells) infiltrate and take over. In short, with age, the thymus changes from a primary lymphoid organ into a fatty tissue (4).
Now for the good news about PURE “White Gold” Colostrum and stop and reverse shrinkage:
First Choice for New Life Colostrum is the pre-milk fluid secreted by the mammary glands of mammals and humans for up to 48 hours. (Just so you know according to PhD Dr Klinesmith “Pure colostrum must be harvested from a mammal at 6 hours or less to be considered “PURE Colostrum”) It serves as life’s first food for newborns during those first crucial hours of life. Many specialized immune modulators and growth factors are found in high concentrations to stimulate over 50 different mission critical processes. These include the rapid development of competent immunity and the growth and maturation of all life-sustaining body tissues.
This may be why research at both CDC and NIH shows that children who are breast-fed have far fewer childhood diseases than those fed on formula.
Used as a natural, whole-food remedy for thousands of years, now medical research shows that adult humans can also receive the full range of benefits from bovine colostrum supplementation. ,
Like what you see here.
Studies are now showing significant gains in fitness with colostrum supplementation. A widely reported study in Australia found a 20% increase in strength, stamina and shortened recovery time for both soccer players and cyclists. Many body builders and fitness experts say colostrum works better than any other legal substance they ever experienced.
The growth factors found in colostrum are now known to enhance muscle tone, burn off body fat, promote skin elasticity and increase bone density. TgF alpha and beta (Transforming growth factors) stimulate production and repair of RNA & DNA, as well as repair of damaged muscle fibers in athletes. EgF (Epithelial growth factor) stimulates enhanced skin healing. IGF-1 (Insulin-like growth factor 1) is able to “promote muscle growth by itself” according to Muscle and Fitness associate editor, Steve Schwade.
Bovine IGF-1 is effective in humans, differing in its structure by only 3 out of 67 amino acids, and bovine colostrum is found to be even higher in IGF-1 than is human colostrum. The growth factors in colostrum stimulate protein synthesis and slow protein breakdown, resulting in increased lean muscle mass. At the same time, they shift the metabolism from burning carbohydrates, to burning more fats.
Olympic skiers taking colostrum experienced less fatigue and improved their performance in a placebo controlled study in Finland. They also showed only half the level of blood creatine-kinase, a marker of muscle injury, compared to placebo control. Another study confirmed that athletes taking colostrum during strength and speed training did in fact show increased blood serum concentrations of IGF-1.
Overall, colostrum is considered as powerful as steroids at generating increased muscle mass when used in conjunction with exercise, but without the risks and side effects.
Studies have shown that the growth factors present in colostrum increase between 2,500 to 4,000% (from 2-5 ng/mg to 50-200 ng/mg) with exposure to acidity. To gain the maximum fitness benefits from colostrum, take it in powder form (empty the capsule in your mouth or onto food) toward the end of a meal, or 45 minutes before a physical workout session with a protein drink like One Step. Friendly flora, which naturally promote a healthy acidity level in the colon may also enhance the benefits of colostrum.
Colostrum also provides a potent array of immune factors including immunoglobins, cytokines, interferon, lactoferrin and transfer factor. Supplementation of these factors can dramatically restore immunity, prevent infection and speed healing and recovery from illness.
Bovine colostrum, in particular, is up to 40 times higher than human colostrum in these immune factors. Plus, only bovine colostrum contains certain glycoproteins and protease inhibitors which naturally protect these immune factors from being digested in the intestinal tract.
Even so, prolonged exposure to stomach acid would decrease colostrum’s immune effects. Swallowing colostrum in a capsule with a large glass of alkaline, anti-oxidant water (coral water or electrolysis water) between meals (or at the very start of a meal) should be optimum for immune benefits.
Immunoglobulins, such as IgA (in blood serum, tears and mucus membranes), IgD (antiviral), IgE (antiviral), IgG (in the lymph and blood, and the most abundant in bovine colostrum) and IgM (antibacterial) are large molecules that attach to foreign invaders. Immunoglobulins make up about 40% of the protein in the blood serum.
So their you have it. Do you think your body could use some good quality colostrum that was harvested from 3 to 6 hours tops? Pure colostrum is what you need tp maintain your optimal health.
Be blessed in all that you do.